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New triterpenic acids from Uncaria rhynchophylla: Chemistry, NO-inhibitory activity, and tandem mass spectrometric analysis.
MedLine Citation:
PMID:  24727084     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Five new oleanane and ursane type triterpenes, namely uncarinic acids F-J (1-5), together with six known triterpenic acids (6-11) were isolated from the stems and hooks of Uncaria rhynchophylla. Structure elucidation of 1-5 was based on the integrated analyses of high-resolution MS data, 1-D ((1)H NMR, (13)C NMR, DEPT) and 2-D (HSQC, HMBC, ROESY) NMR spectra. Compounds 4, 10, and 11 exhibited weak inhibitory effects on LPS-induced NO production in RAW264.7 cells (with IC50 1.48, 7.01, and 1.89μM, respectively) with dexamethasone (IC50 0.04μM) and quercetin (IC50 0.86μM) as the positive controls. 19-OH substituted oleanane triterpenic acids (1, 2, 5, 8) were prone to eliminate CH2O3, whereas those ursane-type encompassing 19-OH (3, 6, 7, 9, 4) were featured by preferred cleavage of H2O while performing the negative collision-induced MS/MS fragmentation on an LTQ/Orbitrap mass spectrometer.
Authors:
Yi-Bei Zhang; Wen-Zhi Yang; Chang-Liang Yao; Rui-Hong Feng; Min Yang; De-An Guo; Wan-Ying Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-10
Journal Detail:
Title:  Fitoterapia     Volume:  -     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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