Document Detail

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches.
MedLine Citation:
PMID:  23016989     Owner:  NLM     Status:  In-Data-Review    
Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.
Paula Jorge; Anália Lourenço; Maria Olívia Pereira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biofouling     Volume:  28     ISSN:  1029-2454     ISO Abbreviation:  Biofouling     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200331     Medline TA:  Biofouling     Country:  England    
Other Details:
Languages:  eng     Pagination:  1033-61     Citation Subset:  IM    
a IBB - Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho , Campus de Gualtar , Braga , 4710-057 , Portugal.
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