Document Detail


New trends in encapsulation of liposoluble vitamins.
MedLine Citation:
PMID:  20600399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liposoluble vitamins (A, D, E, and K) and carotenoids have many benefits on health. They are provided mainly by foods. At pharmacological doses, they can also be used to treat skin diseases, several types of cancer or decrease oxidative stress. These molecules are sensitive to oxidation, thus encapsulation might constitute an appropriate mean to preserve their properties during storage and enhance their physiological potencies. Formulation processes have been adapted for sensitive molecule, limiting their exposure to high temperature, light or oxygen. Each administration pathway, oral, systemic, topical, transdermal and local, requires different particle sizes and release profile. Encapsulation can lead to greater efficiency allowing smaller administration doses thus diminishing potential hypervitaminosis syndrome appearance and side effects. Carrier formulation can be based on vitamin dissolution in lipid media and its stabilization by surfactant mixture, on its entrapment in a matrix or molecular system. Suitability of each type of carrier will be discussed for each pathway.
Authors:
M Gonnet; L Lethuaut; F Boury
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-25
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  146     ISSN:  1873-4995     ISO Abbreviation:  J Control Release     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  276-90     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Affiliation:
INSERM U 646 «Ingénierie de la Vectorisation Particulaire», Immeuble IBT, 10 Rue André Boquel, 49100 Angers, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotenoids / administration & dosage*
Drug Carriers / chemistry*
Humans
Vitamin A / administration & dosage*
Vitamin D / administration & dosage*
Vitamin E / administration & dosage*
Vitamin K / administration & dosage*
Vitamins / administration & dosage*
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Vitamins; 11103-57-4/Vitamin A; 12001-79-5/Vitamin K; 1406-16-2/Vitamin D; 1406-18-4/Vitamin E; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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