| New treatment options for atypical hemolytic uremic syndrome with the complement inhibitor eculizumab. | |
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MedLine Citation:
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PMID: 20865644 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. Often HUS is triggered by Shiga-like toxin- producing ESCHERICHIA COLI. Less common is atypical HUS (aHUS), which is caused by defective complement control. aHUS is associated with mutations in genes encoding complement regulatory proteins in ~50% of patients with this syndrome. Furthermore, autoantibodies that inactivate to factor H have also been linked to the disease. Initial triggers include infections, use of endothelial-affecting drugs, malignancies, transplantation, and pregnancy. Advances in our understanding of the pathogenesis of atypical HUS suggest that complement inhibition may be used as treatment for the disease. We discuss the potential benefit of the complement inhibitor eculizumab for the treatment of aHUS. |
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Authors:
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Ozlem Köse; Lothar-Bernd Zimmerhackl; Therese Jungraithmayr; Christoph Mache; Jens Nürnberger |
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Publication Detail:
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Type: Journal Article Date: 2010-09-23 |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: 36 ISSN: 1098-9064 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 669-72 Citation Subset: IM |
Copyright Information:
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© Thieme Medical Publishers. |
Affiliation:
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Department of Nephrology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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