Document Detail

New transmitters and new targets in the autonomic nervous system.
MedLine Citation:
PMID:  7907243     Owner:  NLM     Status:  MEDLINE    
Several recent findings have made research into the autonomic nervous system even more exciting, such as the revelation that nitric oxide is a major neurotransmitter, the delineation of the physiological roles for purines and vasoactive intestinal peptide, and the discovery that the interstitial cells of Cajal are major target cells for enteric innervation. Nitric oxide is probably the major neurotransmitter evoking inhibitory junction potentials in smooth muscle. ATP is a mediator of non-adrenergic non-cholinergic enteric innervation, as well as being a fast neurotransmitter in peripheral and autonomic neuro-neuronal synapses. The interactions between enteric nerves and both immune cells and interstitial cells of Cajal (as pacemaker cells of gut smooth muscle) are forcing a rethink of many aspects of gut physiology.
C Barajas-López; J D Huizinga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in neurobiology     Volume:  3     ISSN:  0959-4388     ISO Abbreviation:  Curr. Opin. Neurobiol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-12     Completed Date:  1994-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111376     Medline TA:  Curr Opin Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1020-7     Citation Subset:  IM    
Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Autonomic Nervous System / physiology*
Neurotransmitter Agents / physiology*
Reg. No./Substance:
0/Neurotransmitter Agents

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