Document Detail


New tools for the analysis of glial cell biology in Drosophila.
MedLine Citation:
PMID:  21305614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because of its genetic, molecular, and behavioral tractability, Drosophila has emerged as a powerful model system for studying molecular and cellular mechanisms underlying the development and function of nervous systems. The Drosophila nervous system has fewer neurons and exhibits a lower glia:neuron ratio than is seen in vertebrate nervous systems. Despite the simplicity of the Drosophila nervous system, glial organization in flies is as sophisticated as it is in vertebrates. Furthermore, fly glial cells play vital roles in neural development and behavior. In addition, powerful genetic tools are continuously being created to explore cell function in vivo. In taking advantage of these features, the fly nervous system serves as an excellent model system to study general aspects of glial cell development and function in vivo. In this article, we review and discuss advanced genetic tools that are potentially useful for understanding glial cell biology in Drosophila.
Authors:
Takeshi Awasaki; Tzumin Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-08
Journal Detail:
Title:  Glia     Volume:  59     ISSN:  1098-1136     ISO Abbreviation:  Glia     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-07-06     Completed Date:  2011-11-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1377-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts, USA. awasakit@ janelia.hhmi.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Biology / instrumentation*
Drosophila / genetics,  physiology*
Drosophila Proteins / genetics
Gene Expression / genetics,  physiology
Genes, Reporter
Molecular Biology / instrumentation*,  methods*
Mutation / physiology
Neuroglia / physiology*
Transcription Factors / genetics
Transgenes
Upstream Stimulatory Factors
Grant Support
ID/Acronym/Agency:
R01 NS042049-06/NS/NINDS NIH HHS; R01 NS042049-07/NS/NINDS NIH HHS; R01 NS042049-08/NS/NINDS NIH HHS; R01 NS042049-09/NS/NINDS NIH HHS; R01 NS042049-10/NS/NINDS NIH HHS; R21 MH083607-01/MH/NIMH NIH HHS; R21 MH083607-02/MH/NIMH NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/GAL4 protein, Drosophila; 0/Transcription Factors; 0/Upstream Stimulatory Factors
Comments/Corrections

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