| New tools for the analysis of glial cell biology in Drosophila. | |
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MedLine Citation:
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PMID: 21305614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because of its genetic, molecular, and behavioral tractability, Drosophila has emerged as a powerful model system for studying molecular and cellular mechanisms underlying the development and function of nervous systems. The Drosophila nervous system has fewer neurons and exhibits a lower glia:neuron ratio than is seen in vertebrate nervous systems. Despite the simplicity of the Drosophila nervous system, glial organization in flies is as sophisticated as it is in vertebrates. Furthermore, fly glial cells play vital roles in neural development and behavior. In addition, powerful genetic tools are continuously being created to explore cell function in vivo. In taking advantage of these features, the fly nervous system serves as an excellent model system to study general aspects of glial cell development and function in vivo. In this article, we review and discuss advanced genetic tools that are potentially useful for understanding glial cell biology in Drosophila. |
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Authors:
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Takeshi Awasaki; Tzumin Lee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-02-08 |
Journal Detail:
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Title: Glia Volume: 59 ISSN: 1098-1136 ISO Abbreviation: Glia Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-07-06 Completed Date: 2011-11-02 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8806785 Medline TA: Glia Country: United States |
Other Details:
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Languages: eng Pagination: 1377-86 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts, USA. awasakit@ janelia.hhmi.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Biology / instrumentation* Drosophila / genetics, physiology* Drosophila Proteins / genetics Gene Expression / genetics, physiology Genes, Reporter Molecular Biology / instrumentation*, methods* Mutation / physiology Neuroglia / physiology* Transcription Factors / genetics Transgenes Upstream Stimulatory Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS042049-06/NS/NINDS NIH HHS; R01 NS042049-07/NS/NINDS NIH HHS; R01 NS042049-08/NS/NINDS NIH HHS; R01 NS042049-09/NS/NINDS NIH HHS; R01 NS042049-10/NS/NINDS NIH HHS; R21 MH083607-01/MH/NIMH NIH HHS; R21 MH083607-02/MH/NIMH NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/GAL4 protein, Drosophila; 0/Transcription Factors; 0/Upstream Stimulatory Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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