Document Detail


New therapeutic targets for the development of positive inotropic agents.
MedLine Citation:
PMID:  22127109     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Heart failure is associated with significant morbidity and mortality despite significant advances in therapies developed for it. Because impaired cardiac contractility plays a central role in systolic HF, drugs increasing cardiac contractility (positive inotropics) have been widely used for HF treatment. Conventional inotropics that increase cAMP and intracellular Ca2+ levels improve symptoms and hemodynamics, but also increase myocardial oxygen demands, cardiac arrhythmias, and mortality, which decreases their overall therapeutic benefit-risk ratio in HF. Thus, we need new inotropic agents with different mechanisms of action that improve clinical outcomes. This review describes the mechanism of action and preliminary clinical results obtained with these new investigational positive inotropic agents.
Authors:
Juan Tamargo; Juan Duarte; Ricardo Caballero; Eva Delpón
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Discovery medicine     Volume:  12     ISSN:  1944-7930     ISO Abbreviation:  Discov Med     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250006     Medline TA:  Discov Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-92     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, 28040, Spain.
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