| New therapeutic strategies in perinatal stroke. | |
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MedLine Citation:
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PMID: 15379607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perinatal stroke represents an important cause of severe neurological deficits that span the individual's lifetime, including delayed mental and motor development, epilepsy and major cognitive deficits. Most strokes occurring in term births, infants and children can be caused by thromboembolism from intracranial and extracranial vessels and are associated with a variety of risk factors such as birth asphyxia, cardiac diseases, blood disorders, maternal disorders, trauma. Animal models of perinatal stroke have been developed to examine the nature and the time course of the events occurring after the ischemic insult and the possible therapeutic strategies useful in reducing ischemic damage. The present article addresses the potential pharmacological treatments targeting the inflammatory process and apoptotic cell death, with a specific emphasis on the emerging role of statins as neuroprotective agents in perinatal stroke. As a prelude, we will also review advances in our understanding on the mechanisms underlying the hypoxic-ischemic reperfusion injury in the newborn. |
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Authors:
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W Balduini; S Carloni; E Mazzoni; M Cimino |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current drug targets. CNS and neurological disorders Volume: 3 ISSN: 1568-007X ISO Abbreviation: Curr Drug Targets CNS Neurol Disord Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-21 Completed Date: 2004-11-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101151150 Medline TA: Curr Drug Targets CNS Neurol Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 315-23 Citation Subset: IM |
Affiliation:
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Istituto di Farmacologia e Farmacognosia, Università di Urbino Carlo Bo, Via S Chiara 27, 61029 (PU), Italy. walter.balduini@uniurb.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects, physiology Encephalitis / drug therapy, etiology, physiopathology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology, therapeutic use Infant, Newborn Infant, Newborn, Diseases / drug therapy*, etiology, physiopathology* Models, Animal Neuroprotective Agents / pharmacology*, therapeutic use Reperfusion Injury / drug therapy, physiopathology Stroke / drug therapy*, etiology, physiopathology* Thromboembolism / drug therapy*, etiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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