Document Detail


New therapeutic options in heart failure. What's on the horizon? An overview.
MedLine Citation:
PMID:  25215348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure is a complex clinical syndrome responsible for high morbidity and mortality in the world. Despite advances in the management of heart failure, the prognosis of these patients remains poor and there is a critical need for new treatment strategies improving the clinical outcomes. New approaches in heart failure therapies target cellular mechanisms, as well as mechanical and structural aspects of heart failure that are not addressed by recent therapies. These include abnormalities in molecular mechanisms, electrical conduction and ventricular remodeling. This review presents the pathophysiological basis, mechanisms of action and available clinical efficacy and safety data of drugs and mechanical therapies that are currently under development.
Authors:
Eleni S Nakou; Panagiotis E Vardas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of cardiology     Volume:  170     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-09-09     Completed Date:  2014-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-106     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Comorbidity
Forecasting
Heart Failure / drug therapy,  physiopathology,  therapy*
Humans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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