Document Detail


New technologies in the genetic approach to sudden cardiac death in the young.
MedLine Citation:
PMID:  20705407     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Sudden cardiac death (SCD) is a major health problem and constitutes one of the most important unsolved challenges in the practice of forensic pathology due to the failure to determine the cause of death. Particularly, an important number of previously healthy young people who have died suddenly and unexpectedly are consequence of genetic heart disorders, either structural cardiomyopathies or arrhythmogenic abnormalities. The technological approach to analyze this type of genetically heterogeneous disorders is far from easy but nowadays the variety of chemistries and methodologies improves choice. This review offers to the reader a state of the art of the available technologies for the study of genetics of sudden cardiac death, including mutation screening approaches, genome wide association studies, and the recently developed next-generation sequencing.
Authors:
M Brion; I Quintela; B Sobrino; M Torres; C Allegue; A Carracedo
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Publication Detail:
Type:  Journal Article     Date:  2010-08-11
Journal Detail:
Title:  Forensic science international     Volume:  203     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  15-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Genomics Medicine Group, Galician Foundation of Genomic Medicine and University of Santiago de Compostela, CIBERER, Santiago de Compostela, Spain. maria.brion@usc.es
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