| New technologies for the human cytome project. | |
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MedLine Citation:
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PMID: 15471209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytomes or cell systems are composed of various kinds of single-cells and constitute the elementary building units of organs and organisms. Their individualised (cytomic) analysis overcomes the problem of averaged results from cell and tissue homogenates where molecular changes in low frequency cell populations may be hidden and wrongly interpreted. Analysis of the cytome is of pivotal importance in basic research for the understanding of cells and their interrelations in complex environments like tissues and in predictive medicine where it is a prerequisite for individualised preventive therapy. Analysis of molecular phenotypes requires instrumentation that on the one hand provides high-throughput measurement of individual cells and is on the other hand highly multiplexed, enabling the simultaneous acquisition of many parameters on the single cell level. Upcoming technology suitable to this task, such as slide based cytometry is available or under development. The realisation of cytomic technology is important for the realisation of the human cytome project. |
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Authors:
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A Tárnok |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biological regulators and homeostatic agents Volume: 18 ISSN: 0393-974X ISO Abbreviation: J. Biol. Regul. Homeost. Agents Publication Date: 2004 Apr-Jun |
Date Detail:
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Created Date: 2004-10-08 Completed Date: 2005-05-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8809253 Medline TA: J Biol Regul Homeost Agents Country: Italy |
Other Details:
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Languages: eng Pagination: 92-5 Citation Subset: IM |
Affiliation:
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Pediatric Cardiology, Heart Center Leipzig GmbH, University Hospital Leipzig, Leipzig, Germany. tarnok@medizin.uni-leipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Biology
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trends* Computational Biology* Cytological Techniques Cytophotometry Electrophoresis Genome, Human Genomics Humans Image Processing, Computer-Assisted Mass Spectrometry Microscopy, Fluorescence Oligonucleotide Array Sequence Analysis Proteomics Staining and Labeling |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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