Document Detail


New technologies for the human cytome project.
MedLine Citation:
PMID:  15471209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytomes or cell systems are composed of various kinds of single-cells and constitute the elementary building units of organs and organisms. Their individualised (cytomic) analysis overcomes the problem of averaged results from cell and tissue homogenates where molecular changes in low frequency cell populations may be hidden and wrongly interpreted. Analysis of the cytome is of pivotal importance in basic research for the understanding of cells and their interrelations in complex environments like tissues and in predictive medicine where it is a prerequisite for individualised preventive therapy. Analysis of molecular phenotypes requires instrumentation that on the one hand provides high-throughput measurement of individual cells and is on the other hand highly multiplexed, enabling the simultaneous acquisition of many parameters on the single cell level. Upcoming technology suitable to this task, such as slide based cytometry is available or under development. The realisation of cytomic technology is important for the realisation of the human cytome project.
Authors:
A Tárnok
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  18     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    2004 Apr-Jun
Date Detail:
Created Date:  2004-10-08     Completed Date:  2005-05-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  92-5     Citation Subset:  IM    
Affiliation:
Pediatric Cardiology, Heart Center Leipzig GmbH, University Hospital Leipzig, Leipzig, Germany. tarnok@medizin.uni-leipzig.de
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MeSH Terms
Descriptor/Qualifier:
Cell Biology / trends*
Computational Biology*
Cytological Techniques
Cytophotometry
Electrophoresis
Genome, Human
Genomics
Humans
Image Processing, Computer-Assisted
Mass Spectrometry
Microscopy, Fluorescence
Oligonucleotide Array Sequence Analysis
Proteomics
Staining and Labeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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