Document Detail

New technologies for the human cytome project.
MedLine Citation:
PMID:  15471209     Owner:  NLM     Status:  MEDLINE    
Cytomes or cell systems are composed of various kinds of single-cells and constitute the elementary building units of organs and organisms. Their individualised (cytomic) analysis overcomes the problem of averaged results from cell and tissue homogenates where molecular changes in low frequency cell populations may be hidden and wrongly interpreted. Analysis of the cytome is of pivotal importance in basic research for the understanding of cells and their interrelations in complex environments like tissues and in predictive medicine where it is a prerequisite for individualised preventive therapy. Analysis of molecular phenotypes requires instrumentation that on the one hand provides high-throughput measurement of individual cells and is on the other hand highly multiplexed, enabling the simultaneous acquisition of many parameters on the single cell level. Upcoming technology suitable to this task, such as slide based cytometry is available or under development. The realisation of cytomic technology is important for the realisation of the human cytome project.
A Tárnok
Related Documents :
12941329 - Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives impro...
19321709 - Loss of 26s proteasome function leads to increased cell size and decreased cell number ...
22749529 - Sequential posttranslational modifications program fen1 degradation during cell-cycle p...
19617359 - Cellular localization of predicted transmembrane and soluble chemoreceptors in sinorhiz...
12361589 - Microtubules and microfilaments in cell morphogenesis in higher plants.
4038419 - Mini-review. on the possible importance of an intracellular circulation.
24482399 - Lipoprotein cd0873 is a novel adhesin of clostridium difficile.
23007879 - A novel blueprint for "top down" differentiation defines the cervical squamocolumnar ju...
15901349 - S-adenosyl-l-methionine: transcellular transport and uptake by caco-2 cells and hepatoc...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  18     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    2004 Apr-Jun
Date Detail:
Created Date:  2004-10-08     Completed Date:  2005-05-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  92-5     Citation Subset:  IM    
Pediatric Cardiology, Heart Center Leipzig GmbH, University Hospital Leipzig, Leipzig, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Biology / trends*
Computational Biology*
Cytological Techniques
Genome, Human
Image Processing, Computer-Assisted
Mass Spectrometry
Microscopy, Fluorescence
Oligonucleotide Array Sequence Analysis
Staining and Labeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Potential and challenges of a human cytome project.
Next Document:  Low-dose ionizing radiation exposure: understanding the risk for cellular transformation.