| New technique for artificial lung maturation. Direct intramuscular fetal corticosteroid therapy. | |
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MedLine Citation:
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PMID: 10412616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to present a new technique of administration of antenatal corticosteroid therapy in order to cause fetal lung maturation. A single dexamethasone dose of 4 mg was applied directly to the fetal gluteal musculature by ultrasound-guided intramuscular injection 48 h before delivery. This technique of fetal corticosteroid therapy was applied in six cases. Our patients had high risk pregnancies (preeclampsia diabetes mellitus, intracranial hemorrhage, epilepsy, hyperthyreosis). The pregnancies were terminated in the mother's vital interest. The lecithin/sphyngomyelin (US) ratio was < 1.5:1. There were no procedure-related complications. The fetuses were delivered by cesarean, 48 hours later except for the vaginal delivery in the patient in which fetal death occurred in utero. In five cases an uneventful outcome of fetuses indicated that direct fetal corticosteroid treatment improved postnatal lung function in preterm fetuses. A new technique of corticosteroid application successfully prevents respiratory distress in preterm infants decreasing the risk of maternal complications. To our knowledge, this is the first report of fetal intramuscular corticosteroid therapy in the human population. |
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Authors:
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A Ljubić; M Cvetković; V Sulović; N Radunović; O Antonović; D Vukolić; B Popović; S Petković |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental obstetrics & gynecology Volume: 26 ISSN: 0390-6663 ISO Abbreviation: Clin Exp Obstet Gynecol Publication Date: 1999 |
Date Detail:
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Created Date: 1999-09-10 Completed Date: 1999-09-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802110 Medline TA: Clin Exp Obstet Gynecol Country: ITALY |
Other Details:
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Languages: eng Pagination: 16-9 Citation Subset: IM |
Affiliation:
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Institute of Obstetrics and Gynecology, Clinical Center of Serbia, Belgrade, Yugoslavia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dexamethasone
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administration & dosage* Female Fetal Death Fetal Organ Maturity / drug effects Glucocorticoids / administration & dosage* Humans Infant, Newborn Injections, Intramuscular Lung / drug effects, embryology* Pregnancy Pregnancy Complications Respiratory Distress Syndrome, Newborn / prevention & control* Treatment Outcome Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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