Document Detail


New technique for artificial lung maturation. Direct intramuscular fetal corticosteroid therapy.
MedLine Citation:
PMID:  10412616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to present a new technique of administration of antenatal corticosteroid therapy in order to cause fetal lung maturation. A single dexamethasone dose of 4 mg was applied directly to the fetal gluteal musculature by ultrasound-guided intramuscular injection 48 h before delivery. This technique of fetal corticosteroid therapy was applied in six cases. Our patients had high risk pregnancies (preeclampsia diabetes mellitus, intracranial hemorrhage, epilepsy, hyperthyreosis). The pregnancies were terminated in the mother's vital interest. The lecithin/sphyngomyelin (US) ratio was < 1.5:1. There were no procedure-related complications. The fetuses were delivered by cesarean, 48 hours later except for the vaginal delivery in the patient in which fetal death occurred in utero. In five cases an uneventful outcome of fetuses indicated that direct fetal corticosteroid treatment improved postnatal lung function in preterm fetuses. A new technique of corticosteroid application successfully prevents respiratory distress in preterm infants decreasing the risk of maternal complications. To our knowledge, this is the first report of fetal intramuscular corticosteroid therapy in the human population.
Authors:
A Ljubić; M Cvetković; V Sulović; N Radunović; O Antonović; D Vukolić; B Popović; S Petković
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  26     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  1999  
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  16-9     Citation Subset:  IM    
Affiliation:
Institute of Obstetrics and Gynecology, Clinical Center of Serbia, Belgrade, Yugoslavia.
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MeSH Terms
Descriptor/Qualifier:
Dexamethasone / administration & dosage*
Female
Fetal Death
Fetal Organ Maturity / drug effects
Glucocorticoids / administration & dosage*
Humans
Infant, Newborn
Injections, Intramuscular
Lung / drug effects,  embryology*
Pregnancy
Pregnancy Complications
Respiratory Distress Syndrome, Newborn / prevention & control*
Treatment Outcome
Ultrasonography, Prenatal
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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