| New synthetic antithrombotic agents for venous thromboembolism: pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors. | |
| | |
MedLine Citation:
|
PMID: 21047577 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Heparin and low molecular weight heparins have limitations in their efficacy and safety for the prevention and treatment of venous thromboembolism (VTE). New synthetic antithrombotic drugs, designed with the intention of improving the therapeutic window for prophylaxis and treatment, are in various stages of development. Synthetic pentasaccharides include fondaparinux and its long-acting analogue idraparinux. Dabigatran is a direct thrombin inhibitor that has undergone clinical trials for VTE prophylaxis and treatment. Direct factor Xa inhibitors include rivaroxiban, which has shown promising results for VTE prophylaxis and is being studied for VTE treatment, as well as apixaban and betrixaban, which are at earlier stages of clinical validation. These newer agents may represent viable options for prophylaxis and therapy as further clinical studies are performed. |
| | |
Authors:
|
Timothy A Morris |
Related Documents
:
|
18558097 - Sulfated galactan is a catalyst of antithrombin-mediated inactivation of alpha-thrombin. 14967027 - Mechanism of activation of human heparanase investigated by protein engineering. 21916437 - Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin. 21775967 - In vitro reconstitution of the active t. castaneum telomerase. 16185077 - Dual substrate and reaction specificity in mouse serine racemase: identification of hig... 9466817 - The leukocyte nadph oxidase subunit p47phox: the role of the cysteine residues. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinics in chest medicine Volume: 31 ISSN: 1557-8216 ISO Abbreviation: Clin. Chest Med. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7907612 Medline TA: Clin Chest Med Country: United States |
Other Details:
|
Languages: eng Pagination: 707-18 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Pulmonary and Critical Care Medicine, University of California, San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103-8378, USA. t1morris@ucsd.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
HL095089/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Established venous thromboembolism therapies: heparin, low molecular weight heparins, and vitamin k ...
Next Document: Long-term Anticoagulation for venous thromboembolism: duration of treatment and management of warfar...