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New steroidal saponins from the bulbs of Lilium brownii var. viridulum.
MedLine Citation:
PMID:  22960210     Owner:  NLM     Status:  Publisher    
Phytochemical investigation of the bulbs of Lilium brownii var. viridulum led to the isolation of seven new steroidal saponins (1-7), along with eight known analogues (8-15). The new steroidal saponins were identified as 27-O-[(3S)-3-O-β-d-glucopyranosyl 3-methylglutaroyl]isonarthogenin 3-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (1), (24S,25S)-3β,17α,24-trihydroxy-5α-spirostan-6-one 3-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (2), tenuifoliol 3-O-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (3), 26-O-β-d-glucopyranosylnuatigenin (4), 26-O-β-d-glucopyranosylnuatigenin 3-O-β-d-glucopyranoside (5), 26-O-β-d-glucopyranosylnuatigenin 3-O-{α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→6)]}-β-d-glucopyranoside (6), 26-O-[β-d-glucopyranosyl-(1→2)]-β-d-glucopyranosylnuatigenin 3-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (7), using a combination of spectroscopic evidence and chemical methods. The carbohydrate chain of a sugar linked to C-3 of the HMG group (3-hydroxy-3-methylglutarate) in compound 1 is rarely found in nature. Compound 2 possesses a new (24S,25S)-3β,17α,24-trihydroxy-5α-spirostan-6-one aglycon moiety. The disaccharide chain linked to C-26 hydroxy group of the furospirostanol in compound 7 has not been observed from natural sources.
Xiao-Xiao Hong; Jian-Guang Luo; Chao Guo; Ling-Yi Kong
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  Carbohydrate research     Volume:  361C     ISSN:  1873-426X     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  19-26     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
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