| New steroidal saponins from the bulbs of Lilium brownii var. viridulum. | |
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MedLine Citation:
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PMID: 22960210 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Phytochemical investigation of the bulbs of Lilium brownii var. viridulum led to the isolation of seven new steroidal saponins (1-7), along with eight known analogues (8-15). The new steroidal saponins were identified as 27-O-[(3S)-3-O-β-d-glucopyranosyl 3-methylglutaroyl]isonarthogenin 3-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (1), (24S,25S)-3β,17α,24-trihydroxy-5α-spirostan-6-one 3-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (2), tenuifoliol 3-O-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (3), 26-O-β-d-glucopyranosylnuatigenin (4), 26-O-β-d-glucopyranosylnuatigenin 3-O-β-d-glucopyranoside (5), 26-O-β-d-glucopyranosylnuatigenin 3-O-{α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→6)]}-β-d-glucopyranoside (6), 26-O-[β-d-glucopyranosyl-(1→2)]-β-d-glucopyranosylnuatigenin 3-O-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (7), using a combination of spectroscopic evidence and chemical methods. The carbohydrate chain of a sugar linked to C-3 of the HMG group (3-hydroxy-3-methylglutarate) in compound 1 is rarely found in nature. Compound 2 possesses a new (24S,25S)-3β,17α,24-trihydroxy-5α-spirostan-6-one aglycon moiety. The disaccharide chain linked to C-26 hydroxy group of the furospirostanol in compound 7 has not been observed from natural sources. |
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Authors:
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Xiao-Xiao Hong; Jian-Guang Luo; Chao Guo; Ling-Yi Kong |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-8 |
Journal Detail:
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Title: Carbohydrate research Volume: 361C ISSN: 1873-426X ISO Abbreviation: Carbohydr. Res. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: - |
Other Details:
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Languages: ENG Pagination: 19-26 Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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