| New stereoselective intramolecular | |
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MedLine Citation:
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PMID: 11076609 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Efficient 1,4-asymmetric induction has been achieved in the highly stereocontrolled intramolecular [2 + 2] cycloadditions between ketenimines and imines, leading to 1,2-dihydroazeto[2, 1-b]quinazolines. The chiral methine carbon adjacent to the iminic nitrogen controls the exclusive formation of the cycloadducts with relative trans configuration at C2 and C8. The stepwise mechanistic model, based on theoretical calculations, fully supports the stereochemical outcome of these cycloadditions. |
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Authors:
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Alajarin; Vidal; Tovar; Ramirez De Arellano MC; Cossio; Arrieta; Lecea |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 65 ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: UNITED STATES |
Other Details:
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Languages: Eng Pagination: 7512-5 Citation Subset: - |
Affiliation:
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Farmazi Fakultatea, Euskal Herriko Unibertsitatea, P. K. 450, 01080 Vitoria-Gasteiz, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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