| New spin labeled analogues of podophyllotoxin as potential antitumor agents. | |
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MedLine Citation:
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PMID: 9247323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four new nitroxyl labeled derivatives of podophyllotoxin, 4-(2, 2, 6, 6-tetramethyl-1-oxyl-4-piperidyl)oxy-epipodophyllotoxin (4), 4-(2, 2, 6, 6-tetramethyl-1-oxyl-4-piperidyl)oxy-4'-demethylepipodophyllotoxin (5), 4-(2, 2, 5, 5-tetramethyl-1-oxyl-3-pyrrolinyl)formyloxy-epipodophyllotox in (6) and 4-(2, 2, 5, 5-tetramethyl-1-oxyl-3-pyrrolinyl)formyloxy-4'-demethylep ipodophyllotoxin (7), have been synthesized and evaluated for their antitumor activity in vitro. Compounds 5 and 7 showed superior activity to clinically used etoposide (VP-16,2) in their inhibition of leukemia P388, lung cancer A549 and stomach carcinoma SGC-7901 cells. 4'-Demethyl-epipodophyllotoxins 5 and 7 was found to be more active than eipodophyllotoxins 4 and 6 lacking a free phenolic hydroxyl group at C-4'. |
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Authors:
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Y Wang; J Pan; J Shi; Y Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 61 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Zhejiang University, Hangzhou, P.R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis*, pharmacology Electron Spin Resonance Spectroscopy Humans Models, Chemical Podophyllotoxin / analogs & derivatives*, pharmacology Spin Labels* Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Spin Labels; 518-28-5/Podophyllotoxin |
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