Document Detail


New roles for the gamma rhythm: population tuning and preprocessing for the Beta rhythm.
MedLine Citation:
PMID:  12435923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gamma (30-80 Hz) and beta (12-30 Hz) oscillations such as those displayed by in vitro hippocampal (CA1) slice preparations and by in vivo neocortical EEGs often occur successively, with a spontaneous transition between them. In the gamma rhythm, pyramidal cells fire together with the interneurons, while in the beta rhythm, pyramidal cells fire on a subset of cycles of the interneurons. It is shown that gamma and beta rhythms have different properties with respect to creation of cell assemblies. In the presence of heterogeneous inputs to the pyramidal cells, the gamma rhythm creates an assembly of firing pyramidal cells from cells whose drive exceeds a threshold. During the gamma to beta transition, a slow outward potassium current is activated, and as a result the cell assembly vanishes. The slow currents make each of the pyramidal cells fire with a beta rhythm, but the field potential of the network still displays a gamma rhythm. Hebbian changes of connections among the pyramidal cells give rise to a beta rhythm, and the cell assemblies are recovered with a temporal separation between cells firing in different cycles. We present experimental evidence showing that such a separation can occur in hippocampal slices.
Authors:
Mette S Olufsen; Miles A Whittington; Marcelo Camperi; Nancy Kopell
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of computational neuroscience     Volume:  14     ISSN:  0929-5313     ISO Abbreviation:  J Comput Neurosci     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2002-11-18     Completed Date:  2003-03-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9439510     Medline TA:  J Comput Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-54     Citation Subset:  IM    
Affiliation:
Department of Mathematics, North Carolina State University, Raleigh, NC 27659-8205, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Beta Rhythm*
Computer Simulation
Electric Stimulation
Electroencephalography
Excitatory Postsynaptic Potentials
Hippocampus / cytology,  physiology*
Interneurons / physiology
Male
Models, Neurological*
Neural Inhibition
Neural Networks (Computer)*
Neuronal Plasticity / physiology
Noise
Oscillometry
Periodicity
Pyramidal Cells / physiology
Rats
Rats, Sprague-Dawley
Reaction Time / physiology
Time Factors
Grant Support
ID/Acronym/Agency:
MH47150/MH/NIMH NIH HHS

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