| New role of glutamate as an immunoregulator via glutamate receptors and transporters. | |
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MedLine Citation:
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PMID: 21622250 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Accumulating evidence suggests that the amino acid glutamate (Glu) may play a role in mediating immune function. The demonstration of Glu receptors (GluR) and Glu transporters (GluT) on a variety of immune cells suggests that Glu has a functional role in immunoregulation well beyond its role as a neurotransmitter. The extracellular Glu concentration plays a key role in the regulation of GSH synthesis in immune cells via 2 key GluTs (i.e., Xc- and X-AG systems). Emerging evidence also suggests a role of Glu as signaling molecule in immune cells via ionotropic GluRs (iGluRs) and metabotropic GluRs (mGluRs). In vitro, extracellular Glu concentration has been shown to exert a dose-dependent regulation on lymphocyte activation/proliferation. Specifically, Given the exceedingly high intestinal Glu concentration, these finding are suggestive of a potential role for Glu in modulating immune function and promoting tolerance in the gut associated lymphoid tissues. |
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Authors:
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Hongyu Xue; Catherine J Field |
Publication Detail:
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Type: Journal Article Date: 2011-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 3 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 1007-20 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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