| New resorbable polymeric systems with antithrombogenic activity. | |
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MedLine Citation:
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PMID: 15347968 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The synthesis and application as resorbable coatings of vascular grafts of a new polyacrylic derivative of Triflusal (2-acetyloxy-4-trifluoromethyl)benzoic acid, a commercial drug with antithrombogenic properties, are described. The high-molecular-weight polyacrylic system is rather stable in physiological conditions and provides a chemical support for the slow release of the pharmacologically active compound, Triflusal, or its main metabolite (2-hydroxy-4-trifluoromethyl)benzoic acid (HTB). Experiments of deposition and retention of platelets in static basal conditions using plasma-rich medium from blood of sheep, seem to indicate that the polymeric coating of the polyacrylic derivative of Triflusal improves the antiaggregating character for platelets of the surface of small-diameter vascular grafts without the application of other antithrombogenic drugs. |
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Authors:
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G Rodríguez; A Gallardo; J San Román; M Rebuelta; P Bermejo; J Buján; J M Bellón; N G Honduvilla; C Escudero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 10 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2004-09-06 Completed Date: 2005-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 873-8 Citation Subset: - |
Copyright Information:
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Copyright 1999 Kluwer Academic Publishers |
Affiliation:
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Instituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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