Document Detail


New research in macrolides and ketolides since 1997.
MedLine Citation:
PMID:  15992143     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Macrolide and ketolide antibacterials remain a very dynamically active group. To overcome erythromycin A resistance within Gram-positive cocci and bacteria, novel compounds have been semi-synthesised, such as ketolides and C-4'' carbamate erythromycylamine derivatives. The continual efforts of those studying macrolides have led to molecular level investigations into the mechanism of action of these antibacterials. Among all novel derivatives, only telithromycin and AB-773 are currently under development. No real novel developments have been seen with the 15- and 16-membered ring macrolides, however, research is also continuing in this area. This review is an update of our knowledge in the field of macrolides.
Authors:
A Bryskier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  8     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  1999 Aug 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2005-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  1171-94     Citation Subset:  -    
Affiliation:
Hoescht Marion Roussel, 102 Route de Noisy, 93230 Romainville Cedex, France. andre.bryskier@hmrag.com
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