Document Detail


New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461.
MedLine Citation:
PMID:  23225546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acquired chromosome abnormalities in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are among the most valuable determinants of diagnosis and prognosis. In search of new recurrent balanced translocations, we reviewed the Cancer and Leukemia Group B (CALGB) cytogenetics database containing pretreatment and relapse karyotypes of 4,701 adults with AML and 565 with MDS who were treated on CALGB trials. We identified all cases with balanced structural rearrangements occurring as a sole abnormality or in addition to one other abnormality, excluded abnormalities known to be recurrent, and then reviewed the literature to determine whether any of what we considered unique, previously unknown abnormalities had been reported. As a result, we identified seven new recurrent balanced translocations in AML or MDS: t(7;11)(q22;p15.5), t(10;11)(q23;p15), t(2;12)(p13;p13), t(12;17)(p13;q12), t(2;3)(p21;p21), t(5;21)(q31;q22), and t(8;14)(q24.1;q32.2), and additionally, t(10;12)(p11;q15), a new translocation in AML previously reported in a case of acute lymphoblastic leukemia. Herein, we report hematologic and clinical characteristics and treatment outcomes of patients with these newly recognized recurrent translocations. We also report 52 unique balanced translocations, together with the clinical data of patients harboring them, which to our knowledge have not been previously published. We hope that once the awareness of their existence is increased, some of these translocations may become recognized as novel recurring abnormalities. Identification of additional cases with both the new recurrent and the unique balanced translocations will enable determination of their prognostic significance and help to provide insights into the mechanisms of disease pathogenesis in patients with these rare abnormalities.
Authors:
Alison Walker; Krzysztof Mrózek; Jessica Kohlschmidt; Kathleen W Rao; Mark J Pettenati; Lisa J Sterling; Guido Marcucci; Andrew J Carroll; Clara D Bloomfield;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-10
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  52     ISSN:  1098-2264     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-13     Completed Date:  2013-08-20     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-401     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child, Preschool
Combined Modality Therapy
Female
Humans
Karyotype
Leukemia, Myeloid / genetics*,  pathology,  therapy
Male
Middle Aged
Myelodysplastic Syndromes / genetics*,  pathology,  therapy
Prognosis
Stem Cell Transplantation / methods
Translocation, Genetic*
Transplantation, Autologous
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
CA101140/CA/NCI NIH HHS; CA133250/CA/NCI NIH HHS; CA140158/CA/NCI NIH HHS; CA16058/CA/NCI NIH HHS; CA31946/CA/NCI NIH HHS; CA33601/CA/NCI NIH HHS; CA77658/CA/NCI NIH HHS; K12 CA133250/CA/NCI NIH HHS; P30 CA016058/CA/NCI NIH HHS; P50 CA140158/CA/NCI NIH HHS; U10 CA031946/CA/NCI NIH HHS; U10 CA033601/CA/NCI NIH HHS; U10 CA077658/CA/NCI NIH HHS; U10 CA101140/CA/NCI NIH HHS; U10CA032291/CA/NCI NIH HHS; U10CA035279/CA/NCI NIH HHS; U10CA041287/CA/NCI NIH HHS; U10CA047559/CA/NCI NIH HHS; U10CA047577/CA/NCI NIH HHS; U10CA059518/CA/NCI NIH HHS; U10CA077440/CA/NCI NIH HHS; U10CA077658/CA/NCI NIH HHS; U10CA138561/CA/NCI NIH HHS
Investigator
Investigator/Affiliation:
Jeffrey Crawford / ; Sandra H Bigner / ; Daniel R Budman / ; Prasad R K Koduru / ; Clara D Bloomfield / ; Nyla A Heerema / ; Ellis G Levine / ; AnneMarie W Block / ; Harold J Burstein / ; Ramana Tantravahi / ; Paola Dal Cin / ; Nancy L Bartlett / ; Michael S Watson / ; Eric C Crawford / ; Jaime Garcia-Heras / ; David D Hurd / ; Mark J Pettenati / ; Daniel A Vaena / ; Shivanand R Patil / ; Hedy L Kindler / ; Michelle M Le Beau / ; Bruce A Peterson / ; Diane C Arthur / ; Sreenivasa Nattam / ; Patricia I Bader / ; Stephen L Graziano / ; Constance K Stein / ; Barbara A Parker / ; Renée Bernstein / ; Martin J Edelman / ; Joseph R Testa / ; John Lister / ; Gerard R Diggans / ; Robert Diasio / ; Andrew J Carroll / ; Konstantin Dragnev / ; Doris H Wurster-Hill / ; Steven M Grunberg / ; Mary Tang / ; John D Roberts / ; Colleen Jackson-Cook / ; Sameer Rafla / ; Ram S Verma / ; Carl E Freter / ; Judith H Miles / ; Thomas C Shea / ; Kathleen W Rao / ; William Sikov / ; Teresita Padre-Mendoza / ; Harvey B Niell / ; Sugandhi A Tharapel / ; Apar Ganti / ; Warren G Sanger / ; Charles Ryan / ; Kathleen E Richkind / ; Stephen S Grubbs / ; Digamber S Borgaonkar / ; David Van Echo / ; Kathleen E Richkind /
Comments/Corrections

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