Document Detail


New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides.
MedLine Citation:
PMID:  19841808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three component coupling of a 2-methylenetetrahydropyran, an activated aldehyde or ketone and a secondary nucleophile provides an efficient preparation of tetrahydropyranyl ketides, a unit common to many complex natural products.
Authors:
Guohua Liang; Laura J Bateman; Nancy I Totah
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-23
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  6457-9     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
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MeSH Terms
Descriptor/Qualifier:
Aldehydes / chemistry
Ketones / chemistry
Macrolides / chemical synthesis*,  chemistry
Pyrans / chemistry*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
R01 GM064357/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Ketones; 0/Macrolides; 0/Pyrans; 0/spirastrellolide A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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