Document Detail


New prospects in the therapeutic use of somatostatin and its derivatives
MedLine Citation:
PMID:  1678325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery and subsequent clinical application of somatostatine, a polypeptide neurohormone of 14 amino acids, and of its analogs, opens a novel chapter of neuroendocrinology that is still in full evolution and to a large extent unknown. The isolation of an octapeptide, a selective somatostatine analog, permits to prolong its action, in fact it has a halflife of about 140 min in old subjects and about 100 min. in the young. Thanks to its excellent tolerability, the synthetic hormone can be usefully applied in the treatment of acromegaly, gigantism and hypersomatotropinemic conditions in general, and even in other clinical branches, such as treatment of esophageal hemorrhage due to the rupture of varices in liver cirrhosis or to erosion of gastric blood vessels in patients suffering from peptic ulcer disease.
Authors:
A Simeoni; A Agostino; E Vecci; P Iacobelli; P Vitellone; A Iacobelli
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  La Clinica terapeutica     Volume:  137     ISSN:  0009-9074     ISO Abbreviation:  Clin Ter     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-09-18     Completed Date:  1991-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372604     Medline TA:  Clin Ter     Country:  ITALY    
Other Details:
Languages:  ita     Pagination:  275-9     Citation Subset:  IM    
Affiliation:
II Clinica Medica, Università degli Studi di Roma La Sapienza.
Vernacular Title:
Nuove prospettive nell'uso terapeutico della somatostatina e dei suoi derivati.
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MeSH Terms
Descriptor/Qualifier:
Acromegaly / drug therapy
Drug Tolerance
Gastrointestinal Hemorrhage / drug therapy
Humans
Somatostatin / analogs & derivatives*,  therapeutic use*
Chemical
Reg. No./Substance:
51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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