| New promising drug targets in cancer- and metastasis-initiating cells. | |
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MedLine Citation:
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PMID: 20338259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unique properties of cancer- and metastasis-initiating cells endowed with a high self-renewal and aberrant differentiation potential (including their elevated expression levels of anti-apoptotic factors, multidrug transporters, and DNA repair and detoxifying enzymes) might be associated with their resistance to current clinical cancer therapies and disease recurrence. The eradication of cancer- and metastasis-initiating cells by molecular targeting of distinct deregulated signaling elements that might contribute to their sustained growth, survival, and treatment resistance, therefore, is of immense therapeutic interest. These novel targeted approaches should improve the efficacy of current therapeutic treatments against highly aggressive, metastatic, recurrent, and lethal cancers. |
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Authors:
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Murielle Mimeault; Surinder K Batra |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-03-23 |
Journal Detail:
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Title: Drug discovery today Volume: 15 ISSN: 1878-5832 ISO Abbreviation: Drug Discov. Today Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-07-22 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: England |
Other Details:
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Languages: eng Pagination: 354-64 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. mmimeault@unmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / administration & dosage*, pharmacology* Drug Delivery Systems / methods* Drug Resistance, Neoplasm Drug Screening Assays, Antitumor / methods Drugs, Investigational / administration & dosage*, pharmacology* Humans Models, Biological Neoplasm Metastasis / prevention & control* Signal Transduction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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CA111294/CA/NCI NIH HHS; CA131944/CA/NCI NIH HHS; CA133774/CA/NCI NIH HHS; CA78590/CA/NCI NIH HHS; R01 CA078590-12/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Drugs, Investigational |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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