Document Detail


New pluronic-free perfluorocarbon cardioplegia improves myocardial oxygenation.
MedLine Citation:
PMID:  3180395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardioplegic protection with oxygenated lecithin-emulsified methyl adamantane, a perfluorocarbon with high oxygen solubility, was compared with oxygenated crystalloid cardioplegic solution in an ischemic rabbit heart model. The cardioplegic solutions had identical salt compositions with a potassium concentration of 15 meq/l. Eighteen isolated rabbit hearts underwent 180 minutes of global ischemia at 30 degrees C, followed by a 45-minute period of reperfusion at 37 degrees C. During the ischemic period, cardioplegic solution was infused every 30 minutes, and myocardial oxygen extraction was calculated. Left ventricular function was assessed before and after ischemia by measuring left ventricular isovolumic developed pressure and the first derivative of pressure (dP/dt). Cardioplegia oxygen extraction for the methyl adamantane hearts was 230 +/- 11 ml of O2/100 g heart wt and 150 +/- 25 ml O2/100 g heart wt for the crystalloid hearts (p less than 0.05). Recovery of dP/dt at 30 minutes of reperfusion, expressed as a percentage of preischemic control, was 80% +/- 3% for the methyl adamantane hearts and 61% +/- 3% for the crystalloid hearts (p less than 0.05). The developed pressure for the methyl adamantane hearts was 73% +/- 3% and for the crystalloid hearts, 62% +/- 2% (p less than 0.05). In this global ischemia model, perfluorocarbon emulsified with egg-yolk phospholipid improved oxygen delivery and postischemic myocardial performance compared with an oxygenated crystalloid cardioplegic solution.
Authors:
D L Johnson; P S Greene; V L Gott; T J Gardner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  78     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-15     Completed Date:  1988-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  III153-7     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardioplegic Solutions / therapeutic use*
Coronary Disease / drug therapy,  physiopathology
Drug Evaluation, Preclinical
Emulsions
Fluorocarbons / therapeutic use*
Heart / physiopathology
Heart Ventricles
Myocardium / metabolism*
Oxygen Consumption / drug effects*
Phosphatidylcholines
Potassium / therapeutic use
Potassium Compounds*
Rabbits
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Emulsions; 0/Fluorocarbons; 0/Phosphatidylcholines; 0/Potassium Compounds; 0/potassium cardioplegic solution; 7440-09-7/Potassium

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