| New players in the sepsis-protective activated protein C pathway. | |
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MedLine Citation:
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PMID: 20714106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recombinant activated protein C (aPC) improves the survival of patients with severe sepsis, but the precise molecular and cellular targets through which it mediates this effect remain incompletely understood. In this issue of the JCI, Kerschen et al. show that endothelial cell protein C receptor (EPCR) is specifically expressed by mouse CD8+ dendritic cells and that these coordinators of host responses to systemic infection are required for aPC to provide protection against the lethality of sepsis. An additional study, by Cao and colleagues, recently published in the JCI, implicates the leukocyte integrin CD11b in the pathways by which aPC mediates antiinflammatory effects in the context of lethal sepsis in mice, suggesting a common thread of synergistic control of innate immune responses by life-saving aPC therapy. |
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Authors:
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Wolfram Ruf |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-16 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 120 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-15 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 3084-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA. ruf@scripps.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD11b / metabolism Blood Coagulation Factors / metabolism Forecasting Humans Leukocytes / metabolism Mice Protein C / metabolism*, physiology* Receptors, Cell Surface / metabolism Recombinant Proteins / metabolism Sepsis / immunology*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL-060742/HL/NHLBI NIH HHS; HL-077753/HL/NHLBI NIH HHS; HL-31950/HL/NHLBI NIH HHS; R01 HL077753-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11b; 0/Blood Coagulation Factors; 0/Protein C; 0/Receptors, Cell Surface; 0/Recombinant Proteins; 0/activated protein C receptor |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2010 Sep;120(9):3167-78
[PMID:
20714108
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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