Document Detail

New phytotoxic metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee gut.
MedLine Citation:
PMID:  19035568     Owner:  NLM     Status:  MEDLINE    
Two new phytotoxic gamma-lactones, pestalotines A and B (1 and 2, resp.), along with 4-oxo-4H-pyran-3-acetic acid (3) and 6-hydroxyramulosin (=3,4,4a,5,6,7-hexahydro-6,8-dihydroxy-3-methyl-1H-2-benzopyran-1-one; 4), were isolateded from the culture of Pestalotiopsis sp. HC02, a fungus residing in the Chondracris rosee gut. Structures of the new metabolites were elucidated on the basis of their IR, NMR, and MS data. Pestalotines A and B (1 and 2, resp.) significantly inhibited the radical growth of Echinochloa crusgalli with IC(50) values of 1.85 x 10(-4) and 2.50 x 10(-4) M, respectively, comparable to that of 2-(2,4-dichlorophenoxy)acetic acid (0.94 x 10(-4) M) used as a positive control.
Ying Lao Zhang; Hui Ming Ge; Fang Li; Yong Chun Song; Ren Xiang Tan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  5     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2402-7     Citation Subset:  IM    
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, P. R. China, (phone: +86-25-8359-5103; fax: +86-25-8368-6559).
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MeSH Terms
Ascomycota / chemistry*
Echinochloa / drug effects
Grasshoppers / microbiology*
Herbicides / chemistry,  isolation & purification,  pharmacology
Inhibitory Concentration 50
Lactones / chemistry*,  isolation & purification,  pharmacology
Pyrans / chemistry*,  isolation & purification,  pharmacology
Reg. No./Substance:
0/Herbicides; 0/Lactones; 0/Pyrans

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