Document Detail

New physiological insights into dyspnea and exercise intolerance in chronic obstructive pulmonary disease patients.
MedLine Citation:
PMID:  23234451     Owner:  NLM     Status:  In-Data-Review    
Dyspnea and reduced exercise tolerance are common consequences of chronic obstructive pulmonary disease (COPD) and contribute importantly to poor perceived health status. While the origins of dyspnea and reduced exercise tolerance are complex and multifactorial, there is increasing evidence that lung hyperinflation is an important contributory factor that can be targeted for treatment. In this review, the authors summarize current concepts of the origin and clinical and physiological consequences of both static and dynamic lung hyperinflation in COPD. In particular, they review recent studies that have examined the role of lung hyperinflation in dyspnea causation during exacerbations and physical activity in COPD. Finally, current concepts of the mechanisms of symptom relief and improved exercise tolerance following pharmacological lung volume reduction are reviewed.
Pierantonio Laveneziana; Jordan A Guenette; Katherine A Webb; Denis E O'Donnell
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  6     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  651-62     Citation Subset:  IM    
Université de Paris 06, Equipe de Recherche ER 10 UPMC, Laboratoire de Physio-Pathologie Respiratoire, Faculté de Médecine Pierre et Marie Curie (site Pitié-Salpêtrière), Paris, 75013, France.
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