| New photodynamic therapy protocol to treat AIDS-related Kaposi's sarcoma. | |
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MedLine Citation:
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PMID: 16942436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to evaluate the efficiency of photodynamic therapy (PDT) with phenotiazinium compounds (methylene blue and toluidine blue) and excitation by a non-coherent light source (RL50) to treat AIDS-related Kaposi's sarcoma (Sk-AIDS). BACKGROUND DATA: Sk-AIDS is a malignant disease that is recurrent in AIDS patients. Laser-based PDT protocols have been applied to treat Sk-AIDS with relative success. METHODS: A single patient with multiple lesions who had undergone chemotherapy without success was treated with several applications of PDT, and the patient was closely evaluated. The PDT protocol consisted of injecting a mixture of phenotiazinium compounds into the lesions and applying RL50 at 18 J/cm(2). RESULTS: Complete remission with excellent cosmetic result was observed. This result was discussed in terms of the known mechanisms of PDT action and compared with other PDT protocols. CONCLUSION: This inexpensive PDT protocol, which is based on phenothiazinium compounds and RL50, is efficient to treat Sk-AIDS. |
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Authors:
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João P Tardivo; Auro Del Giglio; Luis H Paschoal; Mauricio S Baptista |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Photomedicine and laser surgery Volume: 24 ISSN: 1549-5418 ISO Abbreviation: - Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-31 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222340 Medline TA: Photomed Laser Surg Country: United States |
Other Details:
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Languages: eng Pagination: 528-31 Citation Subset: IM |
Affiliation:
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Department of Oncology, Medical School of Foundation of ABC, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult HIV Infections / complications* Humans Male Photochemotherapy / methods* Sarcoma, Kaposi / drug therapy*, virology Skin Neoplasms / drug therapy*, virology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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