Document Detail

New perspectives on the management of septic shock in the cancer patient.
MedLine Citation:
PMID:  8803620     Owner:  NLM     Status:  MEDLINE    
Septic shock is a common life-threatening problem, usually presenting with fever, tachycardia, tachypnea, and often a source of infection. The cardiac index is increased, with a decreased systemic vascular resistance, and a reversibly decreased ejection fraction with an increased end diastolic volume. The myocardial depression is most likely caused by a circulating humoral substance that depresses myocardial contractility. The initial treatment of septic shock is aggressive fluid resuscitation and antibiotic therapy, with vasopressors and inotropes being indicated in those patients who do not respond adequately to fluids. Therapy directed against the mediators of septic shock is theoretically promising, but to date has not been successful.
J F Toney; M M Parker
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Infectious disease clinics of North America     Volume:  10     ISSN:  0891-5520     ISO Abbreviation:  Infect. Dis. Clin. North Am.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-01-13     Completed Date:  1997-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804508     Medline TA:  Infect Dis Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-53     Citation Subset:  IM    
Infectious Diseases Section, James A. Haley Veterans' Hospital, Tampa, Florida, USA.
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MeSH Terms
Age Factors
Anti-Bacterial Agents / administration & dosage*
Cardiac Output, High
Drug Therapy, Combination / administration & dosage
Infection / diagnosis
Inflammation Mediators / antagonists & inhibitors
Respiratory Distress Syndrome, Adult / diagnosis
Sepsis / diagnosis
Shock, Septic / diagnosis,  physiopathology,  therapy*
Systemic Inflammatory Response Syndrome / diagnosis
Vascular Resistance
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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