Document Detail


New perspectives on iron: an introduction.
MedLine Citation:
PMID:  10522549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron is an essential nutritional element for all life forms. Iron plays critical roles in electron transport and cellular respiration, cell proliferation and differentiation, and regulation of gene expression. Two emerging new functions for iron are its necessary role in supporting transcription of certain key genes required for cell growth and function [eg, nitric oxide synthase, protein kinase C-beta, p21 (CIP1/WAF1)] and its complex role in hematopoietic cell differentiation. However, iron is also potentially deleterious. Reactive oxygen species generated by Fenton chemistry may contribute to major pathological processes such as cancer, atherosclerosis, and neurodegenerative diseases. Iron-generated reactive oxygen species may also function in normal intracellular signaling. Therefore, roles of iron are both essential and extraordinarily diverse. This symposium explores this diversity by covering topics of iron absorption and transport, the regulation of gene expression by iron responsive proteins, the cellular biology of heme, hereditary hemochromatosis, and clinical use of serum transferrin receptor measurements.
Authors:
D H Boldt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  318     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Texas, Health Science Center at San Antonio, 78284-7880, USA.
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / metabolism
Animals
Cell Division
Cell Respiration
Electron Transport
Gene Expression Regulation
Hematopoiesis
Hemochromatosis / metabolism*
Humans
Iron / metabolism*,  physiology*
Macrophages / physiology
Monocytes / physiology
Oxidation-Reduction
Protein Kinase C / metabolism
Reactive Oxygen Species / metabolism*
Receptors, Transferrin / metabolism
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
DK50425/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; 0/Receptors, Transferrin; 7439-89-6/Iron; EC 2.7.11.13/Protein Kinase C; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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