Document Detail

New perspectives in the drug treatment of Kawasaki disease.
MedLine Citation:
PMID:  10935427     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease (KD) has become the leading cause of acquired heart disease in developed countries. Conventional therapy for KD includes intravenous gammaglobulin (2 g/kg as a single dose over 12 hours) and aspirin (acetylsalicylic acid; high dose until the fourteenth day of illness then low dose). Therapy administered within the first 10 days of the onset of the illness has been shown to reduce arterial wall inflammation and thereby prevent the development of coronary artery aneurysm formation. The majority of patients with KD will respond to conventional therapy. However, the management of nonresponders and patients with complications (such as acute thrombosis and chronic coronary artery changes) remains controversial. In this review article, we address some of these controversies and also describe newer treatment modalities that have been used in the management of patients with KD, both in the acute and convalescent stages of the disease.
D Shingadia; S T Shulman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Paediatric drugs     Volume:  1     ISSN:  1174-5878     ISO Abbreviation:  Paediatr Drugs     Publication Date:    1999 Oct-Dec
Date Detail:
Created Date:  2000-08-29     Completed Date:  2000-08-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100883685     Medline TA:  Paediatr Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Division of Paediatric Infectious Diseases, Northwestern University Medical School, The Children's Memorial Hospital, Chicago, Illinois 60614, USA.
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MeSH Terms
Aspirin / therapeutic use*
Coronary Thrombosis / drug therapy,  etiology
Mucocutaneous Lymph Node Syndrome / complications,  drug therapy*
gamma-Globulins / therapeutic use*
Reg. No./Substance:
0/gamma-Globulins; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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