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New perspectives in cell delivery systems for tissue regeneration: natural-derived injectable hydrogels.
MedLine Citation:
PMID:  22865572     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Natural polymers, because of their biocompatibility, availability, and physico-chemical properties have been the materials of choice for the fabrication of injectable hydrogels for regenerative medicine. In particular, they are appealing materials for delivery systems and provide sustained and controlled release of drugs, proteins, gene, cells, and other active biomolecules immobilized.In this work, the use of hydrogels obtained from natural source polymers as cell delivery systems is discussed. These materials were investigated for the repair of cartilage, bone, adipose tissue, intervertebral disc, neural, and cardiac tissue. Papers from the last ten years were considered, with a particular focus on the advances of the last five years. A critical discussion is centered on new perspectives and challenges in the regeneration of specific tissues, with the aim of highlighting the limits of current systems and possible future advancements.
Authors:
Fabiola Munarin; Paola Petrini; Sabrina Bozzini; Maria Cristina Tanzi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-2
Journal Detail:
Title:  Journal of applied biomaterials & functional materials     Volume:  -     ISSN:  2280-8000     ISO Abbreviation:  J Appl Biomater Function Mater     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101586617     Medline TA:  J Appl Biomater Function Mater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
Affiliation:
Biomatlab, Bioengineering Department, Politecnico di Milano, Milan - Italy.
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