| New perspectives on dystonia. | |
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MedLine Citation:
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PMID: 12691475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dystonia is a syndrome of sustained muscular contractions with numerous underlying etiologies. This review examines the varied phenomenology of dystonias, its evolving classification including recent genetic data as well as its clinical investigation and treatment. Although age of onset, anatomical distribution and family history are key elements of the investigation of dystonia, classification increasingly relies on etiologic and genetic criteria. Physiological abnormalities in striato-cortical circuits are common in dystonia but the pathophysiology is still unclear. In recent years, a great deal has been learned on the more common primary dystonias such as primary torsion dystonia and on dystonia-plus syndromes such as dopamine responsive dystonia. Treatment of dystonia has also evolved and there are now a number of therapeutic agents with clear beneficial effects including anticholinergics, benzodiazepines, and botulinum toxin and there is growing interest in neurofunctional surgery including deep brain stimulation. |
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Authors:
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Mélanie Langlois; Francois Richer; Sylvain Chouinard |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 30 Suppl 1 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-04-14 Completed Date: 2003-05-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: S34-44 Citation Subset: IM |
Affiliation:
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Unité des Troubles du Mouvement André-Barbeau, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blepharospasm
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diagnosis Botulinum Toxins / therapeutic use Diagnosis, Differential Dopamine Agents / therapeutic use Dystonia / classification*, diagnosis, physiopathology*, therapy Dystonic Disorders / classification*, diagnosis, physiopathology*, therapy Globus Pallidus / surgery Humans Neurosurgical Procedures Thalamus / surgery Torticollis / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxins; 0/Dopamine Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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