Document Detail

New perspectives on Mars and Venus: unravelling the role of androgens in gender differences in cardiovascular biology and disease.
MedLine Citation:
PMID:  17448726     Owner:  NLM     Status:  MEDLINE    
There are substantial gender differences in the pattern, severity and clinical outcomes of coronary heart disease independent of environmental risk factor exposure. As a consequence, there has been considerable interest in the potential role of sex hormones in atherogenesis, particularly the potential protective effects of oestrogen. However, the failure of the recent clinical randomised trials to show a cardioprotective effect for oestrogen coupled with a growing interest in androgen replacement therapy in elderly men has refocused interest on the role of androgens in cardiovascular biology and disease. Over the last decade, compelling evidence has emerged that sex differences in vascular biology are not only determined by gender-related differences in sex steroid levels but also by gender-specific tissue and cellular characteristics which mediate sex-specific responses to a variety of stimuli. In the vasculature, androgens often act in a gender-specific manner, with differential effects in male and female cells. This gender-dependent regulation may have important implications for understanding the basis of the gender gap in atherosclerosis and may eventually lead to the development of sex-specific treatments for cardiovascular disease. This review will summarise the current data for the role of androgens in gender differences in coronary heart disease and cardiovascular biology.
Martin K C Ng
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-04-19
Journal Detail:
Title:  Heart, lung & circulation     Volume:  16     ISSN:  1443-9506     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-23     Completed Date:  2007-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Department of Cardiology, Royal Prince Alfred Hospital, Heart Research Institute, Camperdown, NSW 2050, Australia.
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MeSH Terms
Androgens / metabolism*
Cardiovascular Diseases / physiopathology*
Sex Characteristics*
Reg. No./Substance:

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