Document Detail


New peptides, hormones and parturition.
MedLine Citation:
PMID:  10065169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This brief review emphasizes the importance of three novel discovered factors produced by fetal membranes, placenta and/or by the fetus itself in regulating uterine contractility. We have shown that, as reported for other hormones and substances, nitric oxide and endothelin may influence myometrial activity in an autocrine/paracrine manner interacting with other well-known agents such as prostaglandins, oxytocin and hormones. We also demonstrated that different isoforms of nitric oxide synthase (NOS) may play different roles throughout gestation and during labor. We have suggested that another peptide produced by trophoblast cells, adrenomedullin, may affect, directly or indirectly, myometrial contractility during pregnancy, although much remains to be learned about the mechanisms controlling adrenomedullin expression by the feto-placental tissues cells during pregnancy. Continued research is necessary to better define the complex interactions that result in parturition, both at term and preterm, and to allow a more rational approach to management of the premature labor, exploring new possible pharmacological solutions.
Authors:
R Di Iorio; E Marinoni; E V Cosmi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  12     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-05     Completed Date:  1999-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM    
Affiliation:
Second Institute of Obstetrics and Gynecology, University La Sapienza, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Endothelins / metabolism*
Female
Humans
Labor, Obstetric / metabolism*
Nitric Oxide / metabolism*
Peptides / metabolism*
Pregnancy
Uterine Contraction / metabolism
Chemical
Reg. No./Substance:
0/Endothelins; 0/Peptides; 10102-43-9/Nitric Oxide; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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