| New peptide nucleic acid analogues: synthesis and applications. | |
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MedLine Citation:
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PMID: 17696820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptide nucleic acids are oligonucleotide mimics characterised by high chemical and enzymatic stability, high specificity and affinity toward complementary DNA/RNA. The lack of charge and polar groups in the backbone decrease their solubility in aqueous environment and their ability to cross cell membranes, reducing their performance in in vivo applications. To improve solubility, increase affinity and specificity of binding and to control recognition between nucleic acids, several analogues bearing modifications on the nucleobase, nucleobase-backbone linker and on the backbone were synthesised. This paper describes the synthesis and applications of Peptide nucleic acid analogues and discusses the potential of analogues for which no application is reported. |
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Authors:
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Soccorsa Pensato; Michele Saviano; Alessandra Romanelli |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: 7 ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: England |
Other Details:
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Languages: eng Pagination: 1219-32 Citation Subset: IM |
Affiliation:
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Università degli Studi di Napoli Federico II, Dipartimento delle Scienze Biologiche, Facoltà di Scienze Biotecnologiche, Napoli, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Nucleic Acid Conformation Peptide Nucleic Acids / chemical synthesis*, metabolism*, pharmacokinetics Protein Binding / physiology Protein Conformation |
| Chemical | |
Reg. No./Substance:
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0/Peptide Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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