| New peptide labels containing covalently bonded platinum(II) centers as diagnostic biomarkers and biosensors. | |
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MedLine Citation:
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PMID: 11082009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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[reaction: see text] Water- and acid-resistant arylplatinum(II) complexes have been covalently bonded to the N-terminus of L-valine, thus providing organometallic biomolecules with excellent stability properties. Owing to the (195)Pt nucleus (I = (1)/(2)), these building blocks are potentially versatile biomarkers (e.g., MRI). Moreover, they display efficient in vitro biosensor characteristics since they detect SO(2) gas selectively and fully reversibly by an instantaneous change of the spectroscopic properties including a diagnostic (195)Pt NMR signal. |
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Authors:
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M Albrecht; G Rodríguez; J Schoenmaker; G van Koten |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Organic letters Volume: 2 ISSN: 1523-7060 ISO Abbreviation: Org. Lett. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-12 Completed Date: 2000-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3461-4 Citation Subset: IM |
Affiliation:
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Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers* Biosensing Techniques* Indicators and Reagents Molecular Structure Organoplatinum Compounds* Peptides / chemical synthesis*, chemistry Platinum* Valine* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Indicators and Reagents; 0/Organoplatinum Compounds; 0/Peptides; 7004-03-7/Valine; 7440-06-4/Platinum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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