| New patterns of diacylglycerol metabolism in intact cells. | |
| | |
MedLine Citation:
|
PMID: 8435076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The metabolism of di[1-14C]octanoylglycerol metabolism was examined in four cell lines: NIH 3T3 fibroblasts, BHK cells, Pam 212 keratinocytes and WEHI 3BD+ cells. We found the direct conversion of 1,2-di[1-14C]octanoyl-sn-glycerol ([14C]diC8) into dioctanoylphosphatidylcholine and dioctanoylacylglycerol, but no formation of phosphatidylinositol. The [14C]diC8 also underwent lipolytic breakdown. In contrast, 1-[1-14C]oleoyl-2-acetyl-sn-glycerol was metabolized exclusively by lipolysis. Our findings support a new scheme for the metabolic termination of diacylglycerol signals. |
| | |
Authors:
|
J Florin-Christensen; M Florin-Christensen; J M Delfino; H Rasmussen |
Related Documents
:
|
6779716 - Changes in the serine-specific transfer ribonucleic acid pattern of guinea pig epidermi... 8185936 - Sperm nuclear chromatin transformations in somatic cell-free extracts. 11389096 - Effects of overexpression of gamma-glutamyl hydrolase on methotrexate metabolism and re... 6322386 - Quantitative microspectrofluorimetry study of the "blocking effect" of 6-aminochrysene ... 23703816 - Liver radiofrequency ablation compromises the biological gut barrier. 15572476 - Metabolic pathway analysis web service (pathway hunter tool at cubic). |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Biochemical journal Volume: 289 ( Pt 3) ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1993 Feb |
Date Detail:
|
Created Date: 1993-03-18 Completed Date: 1993-03-18 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 783-8 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Yale University, New Haven, CT 06510. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3T3 Cells Animals Cell Membrane Permeability Cyclohexanones / pharmacology Diglycerides / metabolism* Lipids / isolation & purification Lipolysis Lipoprotein Lipase / antagonists & inhibitors Mice Phosphatidylcholines / metabolism Phosphatidylinositols / metabolism Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
|
NIDDK-19813/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cyclohexanones; 0/Diglycerides; 0/Lipids; 0/Phosphatidylcholines; 0/Phosphatidylinositols; 1069-87-0/1,2-dioctanoylglycerol; 83654-05-1/1,6-bis(cyclohexyloximinocarbonyl)hexane; 86390-77-4/1-oleoyl-2-acetylglycerol; EC 3.1.1.34/Lipoprotein Lipase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Direct desaturation of intact galactolipids by a desaturase solubilized from spinach (Spinacia olera...
Next Document: Antisera specific for D2 dopamine receptors.