| New pathogenetic aspects of gut dysmotility in aplastic and hypoplastic desmosis of early childhood. | |
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MedLine Citation:
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PMID: 11315273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peristaltic movement of the gut is a function of the alternating contraction and relaxation of circular and longitudinal muscles. This movement is induced by a tendon-like connective-tissue net (TCTN) in the circular and longitudinal muscles, which are both rooted in a connective-tissue plexus layer (CTPL). In children with a therapy-resistant aperistaltic or hypoperistaltic syndrome who had normally-developed enteric innervation, a lack of the TCTN in the muscularis propria was observed. Over the last 2 years, 241 children with chronic constipation were investigated histopathologically; 46 children surgically treated by partial resection of the gut or diagnostically investigated by whole-mount biopsy. Fifteen children had a hypoperistalsis syndrome and 3 had an aperistalsis syndrome. All specimens were native and cut in a cryostat. Enteric innervation was examined by acetylcholinesterase and dehydrogenase reactions. The TCTN in the muscularis propria was stained with picric acid/sirius red. In the children with an aperistalsis syndrome, a complete lack of the TCTN in circular and longitudinal muscles was observed. A CTPL was not developed. The children with a hypoperistalsis syndrome had no CTPL, but had a partly-developed TCTN in the circular and longitudinal muscles, which gradually faded in the direction of the plexus layer. Independent of a well-developed enteric nervous system, a lack of the TCTN in longitudinal and circular muscles and a missing CTPL (aplastic desmosis) abolishes the coordinated peristaltic movement of the gut. An isolated lack of the CTPL in the myenteric plexus (hypoplastic desmosis) results in a hypoperistalsis syndrome. An anomaly of the TCTN in the muscularis propria disturbs gut-muscle mechanics, and is another cause of gut dysmotility. |
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Authors:
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W A Meier-Ruge; A M Holschneider; A F Schärli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric surgery international Volume: 17 ISSN: 0179-0358 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-23 Completed Date: 2001-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
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Languages: eng Pagination: 140-3 Citation Subset: IM |
Affiliation:
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Institut für Pathologie, Universität Basel, Schönbeinstrasse 40, 4003 Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Chronic Disease Connective Tissue / pathology Constipation / pathology, surgery Desmosomes / pathology* Diagnosis, Differential Enteric Nervous System / pathology Female Gastrointestinal Motility / physiology* Hirschsprung Disease / pathology, surgery Humans Intestinal Diseases / pathology*, surgery Intestinal Pseudo-Obstruction / pathology, surgery Male Muscle, Smooth / pathology Peristalsis / physiology* |
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