Document Detail


New paradigms in basophil development, regulation and function.
MedLine Citation:
PMID:  20125116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emerging evidence has shown that basophils perform essential, non-redundant functions in multiple models of acute and chronic Th2 cytokine-dependent immunity and inflammation. In particular, recent studies have shown that basophils are rapidly recruited to the lymph nodes, can function as antigen-presenting cells and are critical for the induction of Th2 cell differentiation and the associated inflammatory responses after exposure to helminth parasites or allergens. In this review, we discuss recent studies that provide new insights into the pathways that control basophil development, regulation and effector function.
Authors:
Mark C Siracusa; Jacqueline G Perrigoue; Michael R Comeau; David Artis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-02
Journal Detail:
Title:  Immunology and cell biology     Volume:  88     ISSN:  1440-1711     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-18     Completed Date:  2010-06-11     Revised Date:  2010-11-29    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Allergens / immunology
Animals
Basophils / immunology*
Cell Differentiation / immunology
Helminthiasis / immunology
Helminths / immunology
Humans
Hypersensitivity / immunology
Inflammation / immunology
Lymph Nodes / immunology
Models, Immunological*
Th2 Cells / immunology*
Grant Support
ID/Acronym/Agency:
AI61570/AI/NIAID NIH HHS; AI74878/AI/NIAID NIH HHS; F31-GM082187/GM/NIGMS NIH HHS; F32-AI72943/AI/NIAID NIH HHS; S10RR024525/RR/NCRR NIH HHS; T32- AI007532-08/AI/NIAID NIH HHS; T32-AI05528/AI/NIAID NIH HHS; T32-AI055438- 06/AI/NIAID NIH HHS; T32-AI060516/AI/NIAID NIH HHS; T32-CA09140-30/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Allergens

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