Document Detail


New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
MedLine Citation:
PMID:  22795899     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.
Authors:
Paula F Carneiro; Samara B do Nascimento; Antonio V Pinto; Maria do Carmo F R Pinto; Guilherme C Lechuga; Dilvani O Santos; Helvécio M Dos Santos Júnior; Jackson A L C Resende; Saulo C Bourguignon; Vitor F Ferreira
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-21
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  -     ISSN:  1464-3391     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Universidade Federal do Rio de Janeiro, Núcleo de Pesquisas de Produtos Naturais, 21944-970 Cidade Universitária, RJ, Brazil.
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