| New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms. | |
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MedLine Citation:
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PMID: 22795899 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole. |
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Authors:
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Paula F Carneiro; Samara B do Nascimento; Antonio V Pinto; Maria do Carmo F R Pinto; Guilherme C Lechuga; Dilvani O Santos; Helvécio M Dos Santos Júnior; Jackson A L C Resende; Saulo C Bourguignon; Vitor F Ferreira |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-21 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-7-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Universidade Federal do Rio de Janeiro, Núcleo de Pesquisas de Produtos Naturais, 21944-970 Cidade Universitária, RJ, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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