Document Detail


New oxazole-based peptidomimetics: useful building blocks for the synthesis of orthogonally protected macrocyclic scaffolds.
MedLine Citation:
PMID:  14627385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[structure: see text] The synthesis of a new family of densely functionalized oxazole-containing amino acids is described. These building blocks were employed for preparing macrocycles containing Lys and Glu residues by a combination of solid- and solution-phase synthesis. The resulting structures are presented as orthogonally protected scaffolds for supramolecular chemistry.
Authors:
Enrique Mann; Horst Kessler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic letters     Volume:  5     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-20     Completed Date:  2004-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4567-70     Citation Subset:  IM    
Affiliation:
Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.
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MeSH Terms
Descriptor/Qualifier:
Biomimetic Materials / chemical synthesis*,  chemistry*
Glutamic Acid / chemistry
Heterocyclic Compounds / chemical synthesis*,  chemistry
Lysine / chemistry
Molecular Structure
Oxazoles / chemical synthesis,  chemistry*
Peptides / chemistry*
Chemical
Reg. No./Substance:
0/Heterocyclic Compounds; 0/Oxazoles; 0/Peptides; 56-86-0/Glutamic Acid; 56-87-1/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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