Document Detail

New oral anticoagulants: a brief review.
MedLine Citation:
PMID:  19326634     Owner:  NLM     Status:  MEDLINE    
This manuscript represents a brief review of the current oral anticoagulants that have come on the scene over the past decade and that are now in various stages of development through the process of phase II and III clinical trials. A brief review of the oral thrombin and direct factor Xa inhibitors is presented to apprise the practicing clinician of the status of these new agents. Efficacy and safety issues are mentioned as they relate to each agent and the need for alternative agents to replace the vitamin K antagonists for long-term anticoagulation therapy. Although none of the agents discussed in the review have been approved for clinical use, data accumulated thus far from the clinical studies have provided some degree of encouragement and optimism for their future approval.
Joseph J Mazza; Steven H Yale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  WMJ : official publication of the State Medical Society of Wisconsin     Volume:  108     ISSN:  1098-1861     ISO Abbreviation:  WMJ     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-05-08     Revised Date:  2009-05-14    
Medline Journal Info:
Nlm Unique ID:  9716054     Medline TA:  WMJ     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Departments of Hematology/Oncology, Marshfield Clinic and Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA.
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MeSH Terms
Administration, Oral
Anticoagulants / administration & dosage*,  adverse effects,  therapeutic use*
Clinical Trials as Topic
Time Factors
Reg. No./Substance:
Erratum In:
WMJ. 2009 Apr;108(2):84

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