Document Detail

New-onset seizure associated with quetiapine and olanzapine.
MedLine Citation:
PMID:  11895056     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case involving a witnessed seizure in a patient receiving concurrent olanzapine and quetiapine. CASE SUMMARY: A 27-year-old white woman was observed to have a seizure while receiving a stable dosage of olanzapine 15 mg/d, with the addition of quetiapine 100 mg in the evening 1 day before the occurrence of the seizure. There were no known risk factors for epilepsy. DISCUSSION: This case reports a new-onset seizure in the context of concurrent olanzapine and quetiapine use. Interpretation is complicated by recent discontinuation of low-dose clonazepam. CONCLUSIONS: While uncommon, seizures can occur with non-clozapine atypical antipsychotics. Caution is indicated when using these drugs with other agents that may lower the seizure threshold.
Dawson W Hedges; Kreg G Jeppson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  36     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-15     Completed Date:  2002-08-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-9     Citation Subset:  IM    
Department of Psychology and the Neuroscience Center, Brigham Young University, Provo, UT, USA.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Dibenzothiazepines / adverse effects*
Pirenzepine / adverse effects*,  analogs & derivatives
Schizophrenia / drug therapy*
Seizures / chemically induced*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/quetiapine; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 28797-61-7/Pirenzepine
Comment In:
Ann Pharmacother. 2003 Jan;37(1):149-50   [PMID:  12503952 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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