| New-onset seizure associated with quetiapine and olanzapine. | |
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MedLine Citation:
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PMID: 11895056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case involving a witnessed seizure in a patient receiving concurrent olanzapine and quetiapine. CASE SUMMARY: A 27-year-old white woman was observed to have a seizure while receiving a stable dosage of olanzapine 15 mg/d, with the addition of quetiapine 100 mg in the evening 1 day before the occurrence of the seizure. There were no known risk factors for epilepsy. DISCUSSION: This case reports a new-onset seizure in the context of concurrent olanzapine and quetiapine use. Interpretation is complicated by recent discontinuation of low-dose clonazepam. CONCLUSIONS: While uncommon, seizures can occur with non-clozapine atypical antipsychotics. Caution is indicated when using these drugs with other agents that may lower the seizure threshold. |
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Authors:
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Dawson W Hedges; Kreg G Jeppson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 36 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-15 Completed Date: 2002-08-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 437-9 Citation Subset: IM |
Affiliation:
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Department of Psychology and the Neuroscience Center, Brigham Young University, Provo, UT, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / adverse effects*, therapeutic use Benzodiazepines Dibenzothiazepines / adverse effects* Female Humans Pirenzepine / adverse effects*, analogs & derivatives Schizophrenia / drug therapy* Seizures / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/quetiapine; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 28797-61-7/Pirenzepine |
| Comments/Corrections | |
Comment In:
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Ann Pharmacother. 2003 Jan;37(1):149-50
[PMID:
12503952
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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