Document Detail

New onset atrial fibrillation after patent foramen ovale closure.
MedLine Citation:
PMID:  19626689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In this study, we evaluated the incidence of new onset atrial fibrillation (symptomatic or detected by routine ECG) after patent foramen ovale (PFO-) closure. BACKGROUND: Although atrial fibrillation is known to occur in some patients following patent foramen ovale closure, the incidence and the risk associated with each device is not well known. METHODS: We evaluated 1,349 consecutive patients who underwent PFO closure with an approved device and examined the incidence and risk factors associated with the development of atrial fibrillation. The patients had a mean age of 50 years and underwent PFO closure for cerebrovascular accident in 696 (51.6%), transient ischemic attack in 610 (45.2%), paradoxical embolism in 22 (1.6%), decompression sickness in 13 (0.9%), and other reasons including migraine headaches in 6 (0.4%) of cases. RESULTS: Over a mean follow-up period of 38.1 +/- 28 months, 53 (3.9%) patients developed new onset atrial fibrillation, which is higher compared with an age-matched population. Of these, 33 (62.3%) patients developed atrial fibrillation within 4 weeks and 8 (15%) within 6 months following PFO closure (totally 77% from 0 to 6 months). The event consisted of a single paroxysm lasting less than 48 hr in 23 patients, resolving either spontaneously or with cardioversion. 40 (75.5%) patients were symptomatic at the time of diagnosis. Thirty (56.6%) patients developed chronic atrial fibrillation. On multivariate analysis, advanced age and use of the STARFlex device predicted atrial fibrillation. CONCLUSIONS: The number of patients in whom atrial fibrillation was detected was relatively low. It is often a self-limited complication of PFO closure that may occur more frequently in elderly patients and those treated with the STARFlex device.
Stephan Staubach; Daniel H Steinberg; Wibke Zimmermann; Nikolaus Wawra; Neil Wilson; Nina Wunderlich; Horst Sievert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  74     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-26     Revised Date:  2010-01-28    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  889-95     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley-Liss, Inc.
CardioVascular Center Frankfurt, Frankfurt, Germany.
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MeSH Terms
Age Factors
Aged, 80 and over
Atrial Fibrillation / diagnosis,  epidemiology,  etiology*,  therapy
Chronic Disease
Foramen Ovale, Patent / therapy*
Heart Catheterization / adverse effects*,  instrumentation
Kaplan-Meiers Estimate
Middle Aged
Prosthesis Design
Retrospective Studies
Risk Assessment
Risk Factors
Septal Occluder Device / adverse effects*
Time Factors
Treatment Outcome
Young Adult
Comment In:
Catheter Cardiovasc Interv. 2009 Nov 15;74(6):896   [PMID:  19902510 ]
Catheter Cardiovasc Interv. 2010 Feb 1;75(2):301; author reply 302   [PMID:  20049956 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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