Document Detail

New observations in the histopathology of erythema nodosum.
MedLine Citation:
PMID:  1194709     Owner:  NLM     Status:  MEDLINE    
Erythema nodosum presents variable clinical and histologic patterns of response in the vessels, septa, and fat lobules of the subcutaneous tissue. Acute or chronic phlebitis with hemorrhage may be commonly observed; acute panniculitis is observed in foci, but at time it may be the principal histologic feature; lymphocytic infiltration of fat lobules is often found, and lymphoid nodules are not infrequent; rarely, chronic granulomatous lesions involve septa or fat lobules; and proliferative lipocyte response may be observed. Because these variable histologic patterns may be coexistent, excision biopsy and multiple sections are necessary to recognize them. The variable histologic features correlate with the different clinical forms: acute nodular, chronic nodular, migrating plaque lesion, cellulitis, and the rate suppurative form. This variety of panniculus response in erythema nodosum can be explained on the basis of host-tissue response to a delayed hypersensitivity reaction to an antigenic stimulus.
R K Winkelmann; L Förström
Related Documents :
16673809 - Dapsone in the treatment of persistent erythema multiforme.
17114779 - Diagnosis of acute q fever by pcr on sera during a recent outbreak in rural south austr...
21862819 - Flat epithelial atypia of the breast: pathological-radiological correlation.
20065559 - Obstructive jaundice due to a pancreatic mass: a rare presentation of acute lymphoblast...
10330209 - Molecular diagnostics in pediatric acute lymphoblastic leukemia.
21977139 - Hydatid cyst of the pancreas causing portal hypertension.
22463829 - Why does my patient have leukocytosis?
3720749 - Radiological changes under effect of mebendazole on univesicular hydatid cysts in the l...
23131749 - Destructive rib lesions in an hiv sero-negative male: an unusual presentation of tuberc...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  65     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / pathology
Erythema Nodosum / complications,  pathology*
Panniculitis, Nodular Nonsuppurative / complications
Thrombophlebitis / pathology
Veins / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of lipid solvents on protein, DNA, and collagen synthesis in human skin: an electron microsco...
Next Document:  Pulmonary elastic tissue in generalized elastolysis (cutis laxa) and Marfan's syndrome: a light and ...