| New observations on the gastroesophageal antireflux barrier. | |
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MedLine Citation:
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PMID: 17950440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of high-frequency ultrasound transducers combined with manometry in the gastrointestinal (GI) tract has yielded important findings concerning the anatomy, physiology, and pathophysiology of the high-pressure zone of the gastroesophageal junction and the sphincteric muscles within. These transducers have made previously invisible portions of the GI tract accessible to investigation. Three distinct high-pressure zones have been identified and correlated with anatomic structures: the extrinsic sphincter (crural diaphragm) and the two components of the intrinsic sphincter (an upper LES and a lower LES [the gastric sling fiber/clasp fiber complex]). This article discusses the possible underlying pathophysiology of gastroesophageal reflux disease; the biomechanics of the gastroesophageal junction high-pressure zone; and the mechanism of action of standard surgical and newer endoscopic therapies for gastroesophageal reflux disease. |
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Authors:
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Larry Miller; Anil Vegesna; Amit Kalra; Ramashesai Besetty; Qing Dai; Annapurna Korimilli; James G Brasseur |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Gastroenterology clinics of North America Volume: 36 ISSN: 0889-8553 ISO Abbreviation: Gastroenterol. Clin. North Am. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2008-01-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706257 Medline TA: Gastroenterol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 601-17, ix Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Temple University Hospital, Gastroenterology Section, 8th Floor, Parkinson Pavilion, Philadelphia, PA 19043, USA. vivi@temple.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Endoscopy, Gastrointestinal / methods* Endosonography / methods* Esophageal Sphincter, Lower / physiopathology, ultrasonography Fundoplication / methods* Gastroesophageal Reflux* / diagnosis, physiopathology, surgery Gastrointestinal Motility / physiology Humans Manometry Pressure Prognosis Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK-59500/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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