| New nucleoside analogs for patients with hematological malignancies. | |
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MedLine Citation:
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PMID: 21320002 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: In the last few years, several new purine and pyrimidine nucleoside analogs have been synthesized and made available for both preclinical studies and clinical trials. Areas covered: This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity as well as the emerging role of newer purine and pyrimidine nucleoside analogs potentially active in lymphoid and myeloid malignancies. A literature review was conducted from the MEDLINE database PubMed for articles in English. Publications from 2000 to October 2010 were scrutinized. The search terms used were clofarabine, nelarabine, forodesine, 8-chloroadenosine, LMP-420, azacitidine, decitabine, sapacitabine, troxacitabine, thiarabine and zebularine in conjunction with hematologic malignancies, leukemia and lymphoma. Conference proceedings from the previous 5 years of the American Society of Hematology, European Hematology Association, and American Society of Clinical Oncology were searched manually. Additional relevant publications were obtained by reviewing the references from the chosen articles. Expert opinion: Several new nucleoside analogs are currently under investigation in preclinical and clinical studies concerning hematological malignancies. Clofarabine, nelarabine, azacitidine and decitabine have been recently approved for the treatment of leukemias and/or myelodysplastic syndromes. Other agents including forodesine, 8-chloroadenosine, LMP-420, sapacitabine, troxacitabine, thiarabine and zebularine seem to be promising for the treatment of lymphoid and myeloid malignancies. However, definitive data from ongoing and future clinical trials will aid in better defining their status in the treatment of hematological disorders. |
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Authors:
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Tadeusz Robak |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 20 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 343-59 Citation Subset: IM |
Affiliation:
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Medical University of Lodz, Department of Hematology,Lodz, Poland robaktad@csk.umed.lodz.pl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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