Document Detail

New norms for a new generation: cognitive performance in the framingham offspring cohort.
MedLine Citation:
PMID:  15371099     Owner:  NLM     Status:  MEDLINE    
A previous publication presented normative data on neuropsychological tests stratified by age, gender, and education based on the Original Cohort of the Framingham Heart Study. Many contemporary investigations include subject samples with higher levels of education, a factor known to affect cognitive performance. Secular change in education prompted the reexamination of norms in the children of the Original Cohort. The study population consisted of 853 men and 988 women from the Offspring Study, free of clinical neurological disease, who underwent a neuropsychological examination, which included tests given to their parents in 1974 to 1976 as well as additional newer tests to provide a more comprehensive battery. The Offspring population overall was more evenly distributed by gender and better educated. Their performance on cognitive tests was superior to that of the Original Cohort. Multivariable analyses revealed that more years of education explained only a part of the cohort differences. These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data.
Rhoda Au; Sudha Seshadri; Philip A Wolf; Merrill Elias; Penelope Elias; Lisa Sullivan; Alexa Beiser; Ralph B D'Agostino
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental aging research     Volume:  30     ISSN:  0361-073X     ISO Abbreviation:  Exp Aging Res     Publication Date:    2004 Oct-Dec
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-02-25     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  7603335     Medline TA:  Exp Aging Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  333-58     Citation Subset:  IM    
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118-2526, USA.
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MeSH Terms
Adult Children
Aging / physiology*
Cohort Effect
Educational Status
Middle Aged
Neuropsychological Tests / standards*
Regression Analysis
Sex Factors
Grant Support
5R01-AG 08122/AG/NIA NIH HHS; 5R01-AG16495-03/AG/NIA NIH HHS; 5R01-NS17950-19/NS/NINDS NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS
Comment In:
Exp Aging Res. 2007 Jul-Sep;33(3):205-71   [PMID:  17497370 ]

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